My primary kit is a multi-purpose kit, most of it on a game cart. But part of the kit is a Kifaru Marauder 2,500ci MOLLE pack with gun bearer, cargo shelf, and Omni belt. (I have a large very discrete pack cover for it.) Since I can only carry 10 to 15 pounds normally, up to 20 in a real pinch for short times, on my back, the Kifaru carries only the basics. A Kifaru E&E 1,000ci pouch/pack is a dedicated survival kit that can be piggy backed to the Marauder, or carried on the game cart, placed where I can grab it and go in case everything must be abandoned on a moment's notice.
Having discovered actual effective 'off-road' rolling packs, such as the Dixon already mentioned, I will be looking at them as an intermediate option to let me carry more with me than the Marauder without having to use the game cart. I plan to incorporate something like the Dixon as part of the game cart load, where I can strap into it and take it and the Kifaru/E&E combo, leaving the heaviest and bulkiest items on the cached game cart. But that is a future project.
Just my opinion.